Deadline is reporting that Thomas Mann and Jenny Slate are in talks to join Irish director Gerard Barrett for Barrett’s next film Brain on Fire, an adaptation of Susannah Cahalan’s best-selling memoir Brain On Fire: My Month Of Madness.

American actress Dakota Fanning has already been cast, with Mann replacing Will Poulter, and set to play Fanning’s boyfriend. Barrett is adapting the screenplay for the film, which follows a young woman’s descent into insanity.

An Irish/Canadian co-production, Brain On Fire will be produced by Charlize Theron, Beth Kono, and A.J. Dix for Denver & Delilah Films and Rob Merilees for Foundation Features. Barrett is also attached as co-producer.

Shooting is set to take place in Vancouver and New York in July, with Mister Smith Entertainment handling sales.

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